2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140984
    m-PEG24-Mal 2579693-28-8
    m-PEG24-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-Mal
  • HY-141117
    Boc-NH-PEG2-C2-NHS ester 2183440-73-3 ≥98.0%
    Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-C2-NHS ester
  • HY-140235
    Boc-NH-PEG15-NH2 2222566-55-2 98.0%
    Boc-NH-PEG15-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG15-NH2
  • HY-W009787
    1-Bromo-6-chlorohexane 6294-17-3 99.18%
    1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs.
    1-Bromo-6-chlorohexane
  • HY-140367
    Bis-Tos-PEG6 42749-27-9 ≥98.0%
    Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-Tos-PEG6
  • HY-140857
    Iodoacetamide-PEG3-azide 1594986-04-5 98.41%
    Iodoacetamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodoacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodoacetamide-PEG3-azide
  • HY-140036
    Propargyl-PEG3-bromide 203740-63-0
    Propargyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-bromide
  • HY-135085
    Thiol-C2-PEG2-OH 56282-36-1
    Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C2-PEG2-OH
  • HY-140058
    Aminooxy-PEG4-propargyl 1835759-78-8 98.0%
    Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Aminooxy-PEG4-propargyl
  • HY-130382
    Propargyl-PEG6-alcohol 944560-99-0
    Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG6-alcohol
  • HY-140963
    Mal-PEG12-NHS ester 2669737-09-9
    Mal-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG12-NHS ester
  • HY-128804
    PEG3-O-CH2COOH 51951-05-4
    PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs.
    PEG3-O-CH2COOH
  • HY-140426
    Boc-Aminooxy-PEG2-C2-amine 252378-69-1 98.0%
    Boc-Aminooxy-PEG2-C2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG2-C2-amine
  • HY-140822
    Bromo-PEG5-azide 1402411-90-8 99.89%
    Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG5-azide
  • HY-130577
    Amino-PEG5-CH2COOH 141282-35-1
    Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG5-CH2COOH
  • HY-130408
    m-PEG6-Amine 184357-46-8
    m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG6-Amine
  • HY-140799
    Azide-PEG8-alcohol 352439-36-2
    Azide-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG8-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG8-alcohol
  • HY-143855
    Biotin-PEG10-NHS ester 98.02%
    Biotin-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG10-NHS ester
  • HY-141217
    m-PEG7-alcohol 4437-01-8 98.33%
    m-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-alcohol
  • HY-130715
    tert-Butyl 11-aminoundecanoate 220851-29-6 99.02%
    tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    tert-Butyl 11-aminoundecanoate
PROTAC Linkers Isoform Comparison

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